NOVEL NA+/CA2+ EXCHANGER INHIBITOR ORM-10962 SUPPORTS COUPLED FUNCTION OF FUNNY-CURRENT AND NA+/CA2+ EXCHANGER IN PACEMAKING OF RABBIT SINUS NODE TISSUE

Background and PurposeThe exact mechanism of spontaneous pacemaking is not fully understood.Recent results suggest tight cooperation between intracellular Ca2+ handling and sarcolemmal ion channels.An important player of this crosstalk is the Na+/Ca2+ exchanger (NCX), however, direct pharmacological evidence was unavailable so far because of the la

Tunnel gates used for water regulation are very important and critical parts of dam safety.This is because they are exposed to the hydrostatic pressure of the total height of the water in the reservoir.In this case study, a nonlinear finite element modelling and simulation of the diversion tunnel gate of the Gokdere Bridge Dam in Adana, Turkey, are

Smart logistics (SL) reflects the digital transformation of the logistics industry, which is key for economic development.Most evaluations are based on the application of technology in SL, and few studies have evaluated SL from a comprehensive perspective.The paper builds the SL development index (SLDI) model from five dimensions based on the drivi

In recent years, Lake Constance has experienced an invasion and domination of three-spined stickleback (Gasterosteus aculeatus) in the pelagic zone, which has coincided with a decline in the native whitefish (Coregonus wartmanni) population.Similar massive invasions of sticklebacks into pelagic zones have been recognized also in marine areas or sma

With the integration of large-scale renewable energy into the LADIES SHIRTS CAREER power grids, cross-regional power trade can play a major role in promoting renewable energy consumption, as it can effectively achieve the optimal allocation of interconnected power grid resources and ensure the safe and economic operation of the power grid.An optimi